Detalhe da pesquisa
1.
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Nature
; 537(7619): 229-233, 2016 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27501246
2.
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection.
Antimicrob Agents Chemother
; 65(6)2021 05 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33753338
3.
Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.
J Antimicrob Chemother
; 75(5): 1218-1227, 2020 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32011682
4.
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30745384
5.
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28848016
6.
Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Bioorg Med Chem Lett
; 27(12): 2702-2707, 2017 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28465105
7.
Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Bioorg Med Chem
; 25(5): 1571-1584, 2017 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28187957
8.
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 8): 1684-98, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-26249349
9.
Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.
Antimicrob Agents Chemother
; 59(11): 7128-31, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26324270
10.
Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.
Antimicrob Agents Chemother
; 57(7): 3021-8, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23587950
11.
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.
Antimicrob Agents Chemother
; 55(5): 1982-9, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21282428
12.
Synthesis and Structure-Activity Relationships of Imidazopyridine/Pyrimidine- and Furopyridine-Based Anti-infective Agents against Trypanosomiases.
ChemMedChem
; 16(6): 966-975, 2021 03 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33078573
13.
Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach.
Trop Med Infect Dis
; 5(1)2020 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32033395
14.
Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei.
RSC Med Chem
; 11(8): 885-895, 2020 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33479683
15.
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
Mol Microbiol
; 68(1): 37-50, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18312275
16.
Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis.
ACS Med Chem Lett
; 10(1): 105-110, 2019 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30655955
17.
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.
Antimicrob Agents Chemother
; 52(10): 3710-7, 2008 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-18644955
18.
The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Acta Crystallogr F Struct Biol Commun
; 74(Pt 4): 245-254, 2018 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29633973
19.
1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy.
ACS Med Chem Lett
; 8(8): 886-891, 2017 Aug 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28835807
20.
New Class of Antitrypanosomal Agents Based on Imidazopyridines.
ACS Med Chem Lett
; 8(7): 766-770, 2017 Jul 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28740614